Breast Cancer Types

Posted by admin | Health | Sunday 18 July 2010 4:45 pm

Breast cancer type

Breast cancer type is categorized by whether it begins in the ducts or lobules, the organs responsible for breast milk production. Medullary carcinoma accounts for 15% of all breast cancer types. This breast cancer type represents 5% of all diagnosis. IPR015525 Breast cancer type 2 susceptibility protein Header EBIDatabasesInterPro Search Open in usermanual InterPro: ” /> Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor with a potential function in the cellular response to DNA damage. Some breast cancer types express one or more of these proteins on their cell surface, while others express none. Media Relations Contacts Online Press Kit Rumors, Myths, and Truths Glossary About the American Cancer Society Breastfeeding, Other Factors May Affect Risk of Breast Cancer TypeAtlanta 2008/08/25 -Factors such as age at menopause as well as a woman?s breastfeeding practices can influence her risk of developing certain types of breast cancer.

The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Their analysis included 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing breast cancer, and 78 triple-negative cases (no expression of estrogen, progesterone, or HER2 receptors). The study also included 1,476 women without breast cancer. ? They added that additional studies on the causes of breast cancer subtypes are needed to better understand the biology of the disease. Learn more about our commitment to providing complete, accurate, and private breast cancer information. The study?s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Women with what is referred to as “triple-negative” breast cancer are more likely than other women with breast cancer to experience a relapse, a new study by Canadian researchers shows. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be “cured” of their disease.

Breast Feeding Will Lowers Risk Of Breast Cancer

Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Understanding the specific type of breast cancer can help you ask better questions and work with your physicians to get the best breast cancer treatments. For more information on the types and stages of breast cancer, watch Beyond the Shock®. Medullary carcinoma accounts for 15% of all breast cancer types. Infiltrating lobular carcinoma is a type of breast cancer that usually appears as a subtle thickening in the upper-outer quadrant of the breast. Making up about 2% of all breast cancer diagnosis, tubular carcinoma cells have a distinctive tubular structure when viewed under a microscope. Typically this type of breast cancer is found in women aged 50 and above. Inflammatory breast cancer is a rare and very aggressive type of breast cancer that causes the lymph vessels in the skin of the breast to become blocked.

Breast Cancer Risk

The study’s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Amanda Phipps, a predoctoral research associate at the Fred Hutchinson Cancer Research Center in Seattle, and her colleagues conducted a study to better understand the specific risk factors for the subtypes of breast cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Both late age at menopause and use of estrogen plus progestin hormone therapy were associated with an increased risk of luminal disease. Finally, no differences in risks associated with number of children or the age when a woman first gave birth were observed by subtype. The study authors concluded that their results indicate that “certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be “cured” of their disease. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the risk of breast cancer. Despite many proposed potential pathways, the mechanisms underlying an association between diabetes and breast cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle, and possibly intake of saturated fat and refined carbohydrates, that may confound this association. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence breast cancer risk, the role of the metabolic syndrome in breast carcinogenesis has not been studied and thus remains unknown.

For more info related to this subject and others please visit Breast Cancer Info

Breast Cancer Info

Genetic Risk Factors In Breast Cancer

Posted by admin | Health | Sunday 11 July 2010 4:45 pm

Breast cancer is the most common cancer and the second leading cause of cancer deaths in women in the United States.  In 2008, approximately 184,450 patients were estimated to be diagnosed with invasive breast cancer, and an estimated 40,930 were estimated to die of this disease.   Furthermore, over 50,000 female carcinoma in situ breast cases would have been diagnosed.  The etiology of breast cancer is poorly understood with multiple genetic and environmental factors involved in the initiation and progression of cancer. 

 

Scandinavian Twin Study:  For years, there has been a hot debate as to whether the cause of breast cancer is genetic or environmental.  Then in 2000, Lichtenstein and his colleagues at the Karolinska Institute in Sweden published their study of 44,788 pairs of twins from the Swedish, Danish, and Finnish twin registries.  In this study, they looked at cancer risk with 28 different types of cancers and did statistical modeling of genetic and hereditary contributions in eleven different cancer types.  For breast cancer, they clearly showed that only 27% of breast cancers were due to genetic factors.  This was an even lower hereditary component than other common cancers such as prostate and colorectal.  This study and others have confirmed the fact that over 70% of breast cancers are influenced by environmental factors.

 

BRCA genes:  Although much attention has been made about hereditary breast cancer, only two genes are commonly tested for breast cancer risk assessment.  These two genes are tumor suppressor genes named “BRCA1″ and “BRCA2″ that are involved with DNA repair.  These two genes only account for about 5% of all breast cancers.  Because of the Scandinavian twin study, most experts believed that there are other yet to be discovered genes involved with breast cancer.  Because the chance of having a BRCA mutation in the general population is so low, genetic testing is not indicated in most patients.  However, if a patient has a family history of breast cancer, then a mathematical model can be used to determine if BRCA testing is indicated.  The likelihood of being a BRCA carrier increases with the number of relatives who had cancer and if the cancers occurred earlier in life.  For example, in families with four or more cases of breast or ovarian cancer under the age of 60, over 80% are found to have a damaged version of BRCA1 or BRCA2.  If a patient is a carrier of one or both of the BRCA1 and BRCA2 genes, her risk of breast cancer dramatically increases.  According to estimates of lifetime risk, about 13.2% (132 out of 1,000 individuals) of women in the general population will develop breast cancer, compared with estimates of 36-85% (360-850 out of 1,000) of women with an altered BRCA1 or BRCA2 gene.  In other words, women with an altered BRCA1 and/or BRCA2 gene are up to eight times more likely to develop breast cancer than women without alterations in those genes.  The BRCA1 mutation confers a higher risk than a BRCA2 mutation.  Women who inherit a damaged BRCA1 gene have a 60-85% chance of developing breast cancer at some stage in their lives and a 20-40% chance of developing ovarian cancer.  For BRCA2, the risks are 40-60% and 10-20%, respectively.  

 

Family History and Breast Cancer:  Although the spotlight in hereditary breast cancer has been directed on the BRCA genes, the majority of patients with a family history of breast cancer are BRCA1 and BRCA2 negative.  Even in these BRCA negative patients, however, there is an increased risk of developing cancer with a family history of breast cancer.   Six factors (unrelated to BRCA genes) have been studied in patients with a family history of breast cancer.  They are as follows:

 

1.  Degree of relationship:  If the family member with a history of cancer is a first degree relative, the increased risk is much greater than for second degree relatives. 

2.  Number of relatives who have had breast cancer:  People with two or more family members who have had breast cancer are at higher risk than those with only one affected relative.

3.  Age of onset of cancer:  If the relative developed breast cancer at an early age (pre-menopausal), the risk is higher than if the relative developed post menopausal breast cancer.

4.  Bilateral breast cancer:  If the relative has a history of bilateral breast cancer, the risk is greater than having a relative with unilateral breast cancer.

5.  Gender of the relative:  If the family member with breast cancer is a man, the risk is higher.

6.  Other related early onset tumors:  If there is a family history of early onset ovarian cancer, this incurs an increased risk for a person.

 

How to decide whether you need the BRCA gene test

 

The following is an excerpt from the American Society of Breast Surgeons:

1.  Early onset breast cancer (diagnosed before age 50)

2.  Two primary breast cancers, either bilateral or ipsilateral
3.  A family history of early onset breast cancer
4.  Male breast cancer
5.  A personal or family history of ovarian cancer
6.  Ashkenazi (Eastern European) Jewish heritage
7.  A previously identified BRCA1 or BRCA2 mutation in the family

Any one of these features alone indicates a risk for harboring a BRCA1 or BRCA2 mutation.  The presence of more than one of these features raises that risk to greater than 10%, the traditional cutoff for recommending a BRCA test. Such patients should have access to BRCA testing.  A simple risk-calculation model based on the prevalence of mutations seen among women tested for BRCA mutations is available at http://www.brcacalculator.com.

Dr. Mai Brooks is a surgical oncologist/general surgeon, with expertise in early detection and prevention of cancer. More at www.drbrooksmd.com, thecancerexperience.wordpress.com and progressreportoncancer.wordpress.com.

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Posted by admin | Health | Tuesday 6 July 2010 4:46 pm

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Posted by admin | Health | Wednesday 6 January 2010 6:45 am

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Terra med Alliance News US anger at new age rules for breast cancer tests

Posted by admin | Health | Wednesday 6 January 2010 6:45 am

 

Terra med Alliance News Doctors and experts are in uproar over new recommendations to raise the age of breast cancer screening, warning more women will die from the disease which already claims some 40,000 lives each year.

Terra med Alliance News : Doctors and experts are in uproar over new recommendations to raise the age of breast cancer screening, warning more women will die from the disease which already claims some 40,000 lives each year.

The high-level United States Preventative Services Task Force of scientists and researchers Monday recommended that breast cancer screening in women should now start at the age of 50 as opposed to 40.

And it further said that women between the ages of 50 to 74 should be screened every two years instead of annually.

“Screening saves lives, and cutting back on screening would cost lives,” said Dr. Timothy Johnson, an oncologist at Holyoke Medical Center in Massachusetts.

“I’m against the proposals to cut back the screening on women between the age of 40 and 50, absolutely,” he told AFP.

Some 210,000 American women are affected by the disease each year, and breast tumors are the most common cancer in women patients at Holyoke.

The task force’s findings came two years after the panel issued a report which looked at the same issue, but did not recommend raising the screening age.

Some wondered whether the recommendations issued Monday were part of a cost-cutting effort as the United States wrestles to reform its health care system, something it wasn’t doing two years ago.

Terra med Alliance News: But if that was the idea, cutting mammograms for younger women was not the way to go, said Dr Christine Pellegrino of the Montefiore-Einstein Center for Cancer Care in New York.

“Are they going to not reimburse mammograms for younger women versus potentially having to absorb the case of a woman who presents years later with advanced breast cancer where you’re talking chemotherapy, surgery, more chemo, radiation and a great potential for recurrence?” Pellegrino, who is director of Montefiore-Einstein’s breast clinic, wondered.

“Not only does that have a huge financial cost but also a devastating psychological impact,” said Pellegrino, who was also opposed to hiking the starting age for breast cancer screening.

“If a woman shows up at 50 for her first screening and they find out she has this big cancer, and you know that if you had screened her a few years earlier you would have found it… whether you’re the patient or the provider, if you have to say, ‘Well, if we had done this two years earlier,’ nobody will recover from that.”

Mammograms currently cost the US public health system, Medicare, between three and five billion dollars a year.

One reason the task force gave for phasing out mammograms for younger women was the higher incidence of false-positive results in the group. These caused significant stress and led to unnecessary biopsies and treatment.

But cancer survivor Debbie Guardian said a false-positive was a small price to pay for catching the real thing in time.

“What’s worse? A lot of stress only to find out it was plain old calcification or a lot of stress to discover you’ve got breast cancer but it’s treatable because you were screened on time?” Guardian, whose doctors confirmed she had breast cancer days after her 50th birthday last year, told AFP.

“I went every single year (for a mammogram) starting at 40. Had I not gone when I was still 49, I wouldn’t have known I had cancer because it wasn’t big enough for me to feel, but it was big enough to be serious,” she said.

“What this esteemed panel of experts is recommending is not wise, to put it politely. Based on personal experience, I wholeheartedly disagree with them,” she said.

Pellegrino said the panel’s recommendations went against years of efforts to raise awareness of breast cancer.

“To start telling women, ‘I know you just turned 40 but we’re not going to do your baseline mammogram’ — the reaction is going to be one of complete visceral disbelief like, ‘What do you mean I’m not going to have my mammogram’?”

According to this year’s report, one life is saved for every 1,900 women aged 40-49 screened for breast cancer, compared to one life for every 1,300 in the 50-59 year age group.

“You may have to screen 1,900 women a year to save one life, but that’s part of cancer screening,” said Johnson. “We see a lot of women in their 40s with breast cancer, and by screening younger women, we save lives.”

Terra med Alliance is a non-profit charity organization dedicated to research, education and advocacy of breast cancer. One of the vision of Terramed Alliance is to provide this community and Internet users with a charity based research and education entity. Advocacy of breast cancer through education is vital to the reduction of this disease.  For any requests and enquiries, please contact at us: cancer@terramedalliance.us www.terramedalliance.us

Terra med Alliance is a non-profit charity organization dedicated to research, education and advocacy of breast cancer. One of the vision of Terramed Alliance is to provide this community and Internet users with a charity based research and education entity. Advocacy of breast cancer through education is vital to the reduction of this disease. For any requests and enquiries, please contact at us: cancer@terramedalliance.us www.terramedalliance.us

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Posted by admin | Health | Saturday 6 June 2009 4:10 am

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Hight Phytoestrogen (especially isoflavonet):

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*Promotes silky shiny hair ,keeps hair pattem bone calcium accumulation

*Enhances breast and skin appearance

*Serves as a anti-wrinkle agent

*Enhances physical and mental ability

*Serves as a fountain of youth

Ingredients: Pueraria Mirifica and other herbs (60 capsules per box)

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- Women with developing cyst at the ovary, breast, and uterus.
- Pregnant women and breast feeking mother should avoid taking this product.
- Women who are taking birth control pill should not take this product.

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